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All over the world, the company colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. the company, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
This colleague provides quantitative analysis of drugs and metabolites from biological matricies to support the company Small-Molecule Global Discovery portfolio. This is accomplished through sample preparation using automated and manual techniques and analysis using liquid-chromatography/mass spectrometry. Colleagues are responsible for the development of "fit-for-purpose" assays and the associated assay troubleshooting and data analysis.
The primary role of the bioanalytical scientist is to provide quantitative analysis of drugs and metabolites from biological matrices in support of drug discovery programs. Fluid and tissue samples from non-regulated in vivo studies are analyzed to assess the pharmacokinetic/pharmacodynamic properties of new chemical entities. This position requires knowledge and experience in the development of quantitative analytical methodologies using primarily triple-quadrupole mass spectrometry. Knowledge of sample preparation, liquid chromatography, and analytical instrumentation are needed as these colleagues are expected to identify assay issues, and perform the associated trouble-shooting. The bioanalytical scientist is expected to utilize assay automation and IT processes to enable efficient bioanalytical support and to recognize opportunities for bioanalytical process improvement. The scientist must demonstrate good written, oral and interpersonal communication as they will interact with cross-functional partners and bioanalytical teams and are expected to promote and share new bioanalytical practices and techniques within the group. This position supports a dynamic and complex portfolio so the scientist will experience changing priorities and must be able to balance analytical rigor and resource burn with the study's goals.
Minimum: B.A. /B.S. degree in chemistry, biochemistry or related field is required with undergraduate research emphasis on the utilization of liquid chromatography, mass spectrometry, or in vivo sample preparation for quantitative analysis or B.A. /B.S. degree with 1-3 years of experience in quantitative analysis from biomatricies.
Desired: M.S. degree in analytical chemistry with a research emphasis on the utilization of liquid chromatography, mass spectrometry, or in vivo sample preparation for quantitative analysis or M.S. degree with 1-3 years of experience in quantitative analysis from biomatricies.
This position is not open at the Ph.D. level.
• Experience in the preparation of biological samples by protein precipitation, solid-phase extraction and liquid-liquid extraction
• Experience in the development of liquid chromatographic separations
• Experience in the operation of triple-quadrupole mass spectrometers.
• Experience in the operations of automation and robotics.
• Knowledge of the underlying principles of chromatography and mass spectrometry
• Knowledge and experience with research informatics systems and tools such as WATSON LIMS
• Demonstration of process continuous improvement.
• Demonstrated ability to investigate and develop new bioanalytical approaches and strategies either independently or through collaboration.
• Good organizational, oral and written communication skills
• Demonstrated ability to work in a matrix team environment
Lifting mobile phase bottles, 1-2 gallon waste LC-MS containers, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. Ability to use pipettes, and centrifuges, etc. Ability to wear masks when working with highly potent biotherapeutics (OEB5) and the ability to work in safety hoods for extended hours.
Other Information - Internal
Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.
EEO & Employment Eligibility
the company is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. the company also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. the company is an E-Verify employer.
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