Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Biotransformation Senior Scientist, to be located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information.
The Pharmacokinetics, Dynamics and Metabolism(PDM) Division, which is part of Discovery Sciences at Janssen Pharmaceutical R & D, is seeking a highly motivated and talented Biotransformation Senior Scientist to provide drug metabolism support for drug discovery and development programs at its Spring House site in PA.
The position will have hands-on lab-based activities including designing and conducting various drug metabolism experiments, interpretation of data, presenting data to team and writing reports. The successful applicant should have extensive hands-on experiences using various biochemical (incubation with various liver subcellular fractions, recombinant enzymes, and hepatocytes) and analytical (LC-radioactivity detector-tandem mass spectrometry) techniques to support in vitro and in vivo drug metabolism studies, automated sample preparation, experience with determination of kinetic parameters of metabolite formation, and hands-on operation and troubleshooting of Thermo/Applied Biosystem LC-MS instruments. The individual is expected to have working knowledge and experience in biochemical or chemical synthesis of metabolites. The candidate should have a working knowledge and broad experience in the optimization of ADMET properties of potential drug candidates in the discovery setting. This includes providing structure-metabolism/bioactivation-relationship to minimize metabolic clearance or reactivity to move project to development.
The individual is expected to perform some research by collaborating with researchers internally or externally. The incumbent is expected to multitask, possess the ability to work well in a multidisciplinary team and be highly flexible in a fast paced environment.