Director, In Vivo Pharmacology, Oncology Research and Development

  • Company: Pfizer
  • Location: Pearl River, New York
  • Posted: December 08, 2017
  • Reference ID: 1609472

ROLE SUMMARY Lead a team of in vivo pharmacologists developing and implementing disease models for the mechanistic characterization and evaluation of novel anticancer therapeutics. This team will provide a critical role in the drug discovery and development process to ensure delivery of high quality in vivo data that enables small molecules and biologics discovery and development programs. The group leader will provide senior in vivo pharmacology expertise to the ORD, contribute to the strategic direction of the in vivo pharmacology discipline at Oncology Pearl River, and work continuously to drive improvements in operational efficiencies. To represent in vivo pharmacology team, play a key role in project teams, and ensure effective communication and collaboration with other teams and function lines. ROLE RESPONSIBILITIES Key efforts for this leader will be to: 1) Oversee development and use of mouse models of cancer including syngeneic mouse models, cell line derived xenografts, patient derived xenograft models, GEMMs, and orthotopic models to evaluate novel anticancer therapeutics. 2) Manage internal and external (academic and contract research organizations) resources to deliver quality data in an efficient manner. This will require proactive identification of processes and systems for transparency and continuous improvement as well as development of key partnerships with partner lines (Medicinal Chemistry, ADME, Biomarkers and Drug Safety groups) and judicious contracting with academic or contract research organizations. 3) Mentor senior scientific staff to design and execute in vivo studies to answer key biological questions in support of project teams. 4) Chair a multi-disciplinary in vivo committee that will evaluate and approve all in vivo study design and ensure appropriate resources for executing these studies. 5) Actively collaborate with in vivo lead in Pfizer Oncology sites in La Jolla and Rinat to load-share across sites and design and implement standardized processes for study execution, data collection and reporting for studies performed internally and at external service providers. 6) Familiarity with the regulatory requirements to run an in vivo facility and remain compliant with IACUC and AALAC regulations. 7) Identify and implement best-fit strategy to prioritize studies to provide preclinical data package for clinical development of key assets. 8) Manage and supervise study planning, protocol design, study implementation and result publishing. 9) Manage internal resource allocation and external collaboration if necessary. QUALIFICATIONS Education & Training: • PhD in a relevant biological scientific discipline with a focus on in vivo cancer research and >10 years experience. Experience in running in vivo studies for immune-oncology compounds preferred. Prior Experience: • Relevant extensive experience in a cancer R&D laboratory environment with pharmaceutical industry or academics required. • Advanced training in contemporary scientific discipline with emphasis on cancer research. • Strong understanding of key components and process of drug discovery, applied pharmacology, and drug development. • Strong working knowledge of oncology disease processes, disease models, and current clinical treatments. • Proven track record to run an in vivo pharmacology group in a matrixed environment. • Experience in managing a broad scientific program utilizing relevant mouse tumor models (syngeneic, orthotopic, GEMMs, PDX) and applied technologies enabling in vivo analyses. • Experience and working knowledge in concepts including but not limited to genetic engineering, stable gene expression/knockdown platforms, cell and tumor biology, molecular profiling methodologies, histology/immunohistochemistry, FACS, in vivo imaging, etc. • Strong communication skills and ability to work effectively across multiple multidisciplinary teams. Organizational Relationships: • Will report to the Vice President/CSO of Targeted Therapeutics Discovery within ORD • This position requires extensive collaboration with all units of the ORD, most notable Tumor Cell Biology and Precision Medicine in La Jolla as well as the in vivo Pharmacology group(s) in Rinat. Resources Managed: Mentoring and/or managing in vivo pharmacology colleagues, to provide technical and strategic guidance, aligned with development of key data in support of oncology discovery and development teams and programs. Oversight of a team comprised of 14 scientists and contingent workers Additional Information: Grade: 16 Eligible for Relocation Package Eligible for Employee Referral Bonus EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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