Functional Genomics Senior Scientist - Primary Pharmacology Group
Groton , Connecticut
March 21, 2017

About the company
A career at the company offers opportunity, ownership and impact.

All over the world, the company colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. the company, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description
the company colleagues have many perspectives, many backgrounds and many strengths. But we share one goal: to make the world a healthier place. Our investment in people is a commitment to strengthen an already remarkable company. the company is a place for people who strive to learn, grow and lead.

Worldwide Research and Development at the company combines research and technology units that have deep disease area expertise with partner lines that deliver cutting-edge science, generating an efficient R&D operating model, to discover and develop innovative therapies through advancing small molecules and biotherapeutics, including vaccines.

• This laboratory scientist will collaborate closely with colleagues to lead mid- to high-throughput phenotypic screening efforts optimally designed to enable identification of new targets or mechanisms of action.
• The scientist will develop relevant cell-based assays and adapt for mid- to high-throughput screening of genomic reagents (RNAi and CRISPRs) and/or small molecules.
• The scientist will independently oversee phenotypic screening efforts from conception/idea phase through assay development, screening, analysis and hit follow-up.
• The successful candidate will supervise and mentor team members
• The scientist will lead efforts to identify, evaluate and implement innovative technologies and methods that push the envelope of phenotypic screening and the utilization of physiologically-relevant cell models.

The successful candidate will join a team of scientists within the Primary Pharmacology Group which is focused on the design, development, optimization and execution of in vitro plate based screening funnels supporting early Research Unit portfolios. The group also provides the cellular reagent expertise to apply physiologically relevant approaches to target-based and phenotypic screening efforts. Disease areas of focus for the group include Inflammation, Immunology, Neuroscience, Cardiovascular/Metabolic, and Rare Diseases.
We are seeking a highly motivated cell and molecular biologist to perform medium- to high-throughput cell-based phenotypic screens. The successful candidate will combine expertise in high-content/high-throughput screening, molecular biology, and complex cellular models, to support and accelerate the identification of novel targets and mechanisms across a diverse discovery portfolio. Screening efforts will include small molecule and genomic screening strategies including RNAi- and CRISPR-based screens. This individual will collaborate across multiple groups and will lead in the design and validation of physiologically relevant assays, screening execution, data analysis, and hit follow-up for phenotypic screening efforts. The individual will serve as a project point of contact for the drug discovery project teams and will be asked to bring strategic insight into the design of the screening campaign, ensuring the development and progression of an appropriate and rational strategy to pursue novel targets and mechanisms of action. The candidate will possess strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple partners (e.g. therapeutic area teams, Chemistry and Biology leads, ADME and Safety lines and Outsourcing vendors). He/she should demonstrate personal leadership within the group, scientific leadership both at the bench and in project teams, and be adept at multi-tasking. He/she will be expected to mentor more junior scientists in the group to drive team success.
Successful candidates will be expected to:
• Have extensive experience in independently developing in vitro phenotypic cell-based assays and adapting these for HTS.
• Have experience working with physiologically relevant cell models (iPSC-derived models, human primary cells, 3D cultures), particularly with the application and adaptation of these cell models for mid- to high-throughput screens.
• Possess a demonstrated proficiency in high-content screening. This includes familiarity with HCS imaging platforms, hands-on experience with HCS instrumentation and proficiency in the use of image analysis software. Demonstrated ability to apply this knowledge to the execution of high-quality phenotypic screening efforts is also required.
• Expertise in flow cytometry is a plus
• Be skilled in standard molecular biology techniques, with emphasis on RNAi and gene editing (CRISPR) methods, and the application of these methods to genomic screening efforts.
• Have hands-on experience with high-throughput screening, including HTS technology platforms and associated automation solutions, process, and data analysis.
• Lead efforts to identify, evaluate, and implement new technologies and methods that push the boundaries of genomic screening.
• Have a current grasp of the key hurdles of phenotypic drug discovery and new target-ID efforts, and an awareness of the various approaches to address these challenges.
• Demonstrate ability to interpret and integrate in vitro data in the context of physiology
• Be proficient in designing experiments to address key scientific questions
• Be a strategic and innovative thinker with an ability to adapt technologies for novel applications
• Mentor and develop less experienced staff to drive team success.
• Adopt a Continuous Improvement mindset to improve quality, efficiency and/or cost of processes
• Promote the company High content phenotypic screening capabilities and reputation through external publications and presentations.
• Maintain up to date electronic laboratory notebooks and records in accordance with the company policy.
• Comply with all safety training and good laboratory practices.
• Be highly motivated, highly organized and possess excellent verbal and written communication skills
• Show significant ability to work effectively in a matrixed, team-oriented environment.

• Minimum qualification PhD or equivalent with 4+ years of relevant experience to drug discovery in cellular assays, high-content screening and molecular biology OR MSc with 10+ years of industry experience
• Prior experience in a laboratory working as part of a multi-disciplinary team focused on the discovery of novel therapeutic agents.
• Experience with in vitro high content phenotypic assays, data analysis, QC, and visualization
• Cell biology and physiologically relevant cell based assay experience essential
• Experience with troubleshooting technical assays and protocols
• Experience in designing and developing high content cell based assays and proven ability to drive improvements in assay execution
• Demonstration of excellent computer, verbal and written communication skills.
• Demonstrated examples of personal and scientific leadership
• Have a sustained track record of delivering high quality data meeting the needs of teams.
• Experience of successfully interacting with and meeting the needs of stakeholder groups is essential as well as having a customer focus.
• Experience of interacting with other groups in related areas such as material management, automation and informatics is essential.

At the company, we believe in helping people lead healthier lives - from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits as well as a number of additional programs.
The Primary Pharmacology group offers an exciting, fast-paced, supportive environment for colleagues, and fosters a culture encouraging openness, innovation and ownership of our science. We aim to provide continual scientific and growth opportunities for personal development commensurate with a colleague's goals and experience.

Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and to work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

• Travel is not required, however there will be opportunities to travel occasionally to Cambridge, MA to partner with Research Unit project teams and attend appropriate meetings and conferences.
• Compliance with laboratory safety practices.

Other Information - Internal
Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

EEO & Employment Eligibility
the company is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. the company also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. the company is an E-Verify employer.

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