Immunology Lead
Location:
Cambridge , Massachusetts
Posted:
October 22, 2017
Reference:
1702439


Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Immunology Lead in our Cambridge office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As an Immunology Lead working on the Global Drug Safety research and evaluation team, you will be empowered to h elp direct pharmaceutical drug project teams with expert advice on how to design safer, more effective cell, protein and small molecule immunotherapies and s teer drug discovery teams to make safer medicines using experience, in-house, and literature data , and a typical day will include:

OBJECTIVES:
  • Make Immunotherapy Safer | The next generation of immunotherapies come with uncharted safety risks. Help direct pharmaceutical drug project teams with expert advice on how to design safer, more effective cell, protein and small molecule immunotherapies.
  • Lead Immunotoxicity Strategy | Lead the global strategy for designing & delivering of state of the art immunoassays to detect & de-risk immune-mediated toxicities for candidate drug molecules.
  • Immunology Problem Solving | Unwanted immune activation and inhibition can derail even the most promising drug projects. Lead problem-solving teams to help save these projects & make safer drugs for patients.

ACCOUNTABILITIES:
  • Develop and deliver novel immune assays, including traditional immune cell culture as well as advanced organ-on-a-chip technologies
  • Use genomics, molecular & cellular biology to investigate mechanisms of drug-induced toxicity
  • Steer drug discovery teams to make safer medicines using experience, in-house, and literature data




Qualifications:



EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
  • PhD in Immunology or related field with 3+ years of industry experience.
  • Experience with advanced cell culture approaches with cell lines, primary cells, and iPSC cells.
  • Cell and molecular biology skills including flow cytometry, application of knock-out, knock-down technology, gene expression analysis, and biomarker assay development and validation
  • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO
  • Broad scientific knowledge including immunology, pharmacology, toxicology, pathology, physiology and biochemistry.
  • Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for derisking drug candidates.
  • Experience with liver, cardiovascular, gastrointestinal, or immunotoxicity toxicity assays.
  • Skills in pathway analysis, network pharmacology
  • Strong interpersonal and organizational skills
  • Excellent oral and written communication skills

LICENSES/CERTIFICATIONS:
  • DABT certification a plus, but not necessary

PHYSICAL DEMANDS:
  • Routine demands of an office based environment.

TRAVEL REQUIREMENTS:
  • Ability to travel domestically and internationally, 15%

WHAT TAKEDA CAN OFFER YOU:
  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

Learn more at takedajobs.com .

Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx

No Phone Calls or Recruiters Please.

#LI-JT1


A little about us:
Takeda fosters an inclusive environment where all employees are empowered to shine.

Know someone who would be interested in this job? Share it with your network.