Investigator/Sr. Investigator, Mass Spectrometrist
King of Prussia , Pennsylvania
September 23, 2017
Basic qualifications:
• PhD in Analytical Chemistry, in a mass spectrometry related discipline, preferably with post-doctoral experience
• At least 3 years of experience in structural identification using Mass Spectrometry preferably in industry
• Track record of innovation in the field of mass spectrometry supported by publications and presentations at international conferences

Preferred qualifications:
• Knowledge of state-of-the-art high resolution LC-MS and GC-MS instrumentation (e.g. Q-Tof and Orbitrap) in order to provide key information for projects at all stages of pharmaceutical development (from early phase development to marketed product support).
• Proven track record of structural characterisation/elucidation work of small molecules by mass spectrometry (LC-MS and/or GC-MS) - identification of metabolites/impurities/degradants by mass spectrometric techniques
• Experience in analysis of biomolecules by mass spectrometry is an advantage
• Proven track record of development of novel LC-MS and GC-MS methodology
• Experience in developing quantitative analysis methods using mass spectrometric techniques
• Experience in regulated GxP laboratory is a plus
• Strong communication and interpersonal skills
• Project leadership skills
• Knowledge of spectroscopic techniques other than mass spectrometry would be an advantage, e.g. NMR, vibrational spectroscopy
• Experience in troubleshooting MS methods

Has a role under guidance of the Team Leader to:
• Plan, design and execute work/experimental programmes to further the course of Discovery and Development Projects / programmes and enable key decisions, in particular using mass spectrometry expertise (both LC-MS and/or GC-MS qualitative and quantitative).
• Ensure appropriate use of mass spectrometry to define control strategies for New Chemical Entities (NCEs).
• Explore and implement innovative mass spectrometry methodology and procedures.
• Demonstrate scientific judgment and initiative in the achievement of defined objectives, including technical problem solving.
• Demonstrate a sound practical understanding of mass spectrometry and processes, procedures used in mass spectrometry.
• Plan and communicate effectively and identify technical or resource issues and propose/discuss solutions and strategies with team members and more senior staff.
• Demonstrate a high level of problem solving capability and ability to identify and troubleshoot unexpected results or findings.
• Contribute to regulatory dossiers and author/review expert reports.
• Comply with the requirements of Quality, Safety and GSK policies and procedures and ensure that GSK intellectual property is protected.
• Knowledge of closely related scientific disciplines as they apply to drug discovery/development.
• Ability to contribute to and effectively work within matrix teams and with colleagues in other divisions and also colleagues in same divisions e.g. NMR.
• Self motivated flexible approach with good organizational skills and ability to communicate in a scientific manner.
• Ability to evaluate potential innovative research areas and/or apply innovative solutions to project problems.
• Working knowledge of GxP requirements, SOPs and policies.
• Appropriate knowledge of regulatory requirements as applied to the drug development process.
• Operational knowledge of laboratory/plant equipment.
• Leadership of cross-functional projects and ability to lead matrix teams
• If in a supervisory role, has the ability to supervise, train, develop and motivate others

Contact information:

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