A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued. This is an exciting time to be at Pfizer. Our Pharmacometricians have an important role in influencing the discovery and development of drugs. It's fascinating, vital work and you could be part of it. Pharmacometricians at various US locations (Collegeville, PA; Groton, CT; La Jolla, CA, Cambridge, MA and NYC) In this key role as a member of our Global Pharmacometrics group within the Clinical Pharmacology Department, you will be responsible for providing expert study/program design, data analytical and interpretation inputs to our various Research, Development and Business Unit organizations. The successful candidates will work as partners of disease area aligned multi-disciplinary teams in providing model informed drug discovery and development expertise and leadership to a variety of through to loss of patent exclusivity. Of key importance will be the formation and maintenance of effective collaborations with amongst others, statistical, clinical and clinical pharmacology members of these teams. Pharmacometricians provide strategic input into pre-clinical discovery, development and post-approval plans quantifying the risk associated with particular study designs or program strategies and communicating/dissemination of the results. They are responsible for the use of a variety of innovative quantitative methods to integrate knowledge of pharmacokinetics, a variety of response variables (including pharmacodynamic, clinical outcome and undesirable effects), patient characteristics and disease mechanism/states, statistics, study/experimental design, clinical trial simulations, meta-analytical evidence synthesis and quantitative techniques to facilitate quantitative decision making thereby increasing drug research and development efficiency. In addition to the disease specific project activities the successful candidates will forge collaborative relationships with Pharmacometric colleagues within the Global Pharmacometrics community (currently based in USA, UK, China and Japan), other subject matter specialists and groups external to the organization (leading academics, external service providers etc.). The successful candidates will work with colleagues to ensure Pfizer's position as a leader in the use of quantitative approaches supporting drug research and development strategies and worldwide registration of new medicines. Pharmacometricians routinely interact with internal governance bodies, regulatory agencies and external opinions leaders. They are expected to influence the external environment by advancing their discipline and through external presentations and publications. #LI-SA1 • Hands-on modelling and simulation. • Support model informed drug discovery and development (MID3) strategies. • Interaction with clinical pharmacology and other project team colleagues including clinicians and statisticians. • Collaboration with the global Pharmacometric community. The ideal candidates will have a doctorate degree with demonstrated expertise in Pharmacometrics and strong quantitative skills (e.g. experience in mechanistic modelling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population PK and PK-PD modelling, and clinical trial simulations). We encourage applicants from different disciplines including pharmaceutical sciences, biostatistics, medicine, engineering, etc. Candidates with significant experience are sought as well as recent graduates. In addition to professional challenge, we offer a culture that supports and encourages ideas, and recognizes individual contribution. Moreover, the salary and extensive benefits are everything you'd expect from a world leading company A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.