PostDoc Fellow -Elucidating the mechanisms of gastrointestinal responses that limit therapeutic utility of oncology drugs
Location:
Waltham , Massachusetts
Posted:
September 10, 2017
Reference:
R-003877
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
Drug Safety and Metabolism
One of the greatest challenges when discovering and formulating effective medicines lies in mapping their pharmacokinetic properties - how they'll react within the human body. You'll ensure our drug products are safe for clinical trials, and ultimately safe to deliver as novel treatments to patients. To make that happen, you'll be working with truly cutting-edge in silico, in vivo, cellular and molecular technologies to push the boundaries of predictive science.
Main Duties and Responsibilities
You'll have the opportunity to identify mechanisms by which oncotherapeutics affect adult intestinal stem cells, progenitor cells, and differentiating enterocytes.  Your work will utilize cutting-edge molecular and cellular biology techniques to dissect essential elements of stem cell self-renewal and maturation in the intestine.  In addition to expanding frontiers in stem cell biology, your work will directly contribute to understanding the adverse mechanisms that are presently prohibitive for entirely new classes of oncotherapeutics.   
You will be part of a post doc program that aims to offer exposure to drug discovery science and careers while maintaining your ability to publish.  While you will have the opportunity for collaborative support from scientists working on diverse oncology drug discovery projects, your work will focus exclusively on discovering novel mechanism limiting cancer therapy and publication thereof.
Key tasks will be to define intestinal stem cell and differentiating enterocyte populations using in vitro , in vivo , and in silico methodologies and quantify their sensitivity to various pharmacological agents.  You will use bioinformatics to identify key transcriptional regulators of intestinal stem cell self-renewal and proliferation. You'll test the essentiality of the identified genes in cutting-edge organoid systems and identify their key downstream targets, and verify your findings in vivo using transgenic animal systems.  We'll encourage you to publish your findings in high-impact, peer-reviewed scientific journals. Working collaboratively with experts internally and externally across various disciplines you'll also present results externally at scientific conferences and meetings. 
Essential requirements
  • PhD and/or MD in relevant discipline, such as molecular biology, physiology, pharmacology or toxicology
  • Expertise with standard molecular biology techniques, including mammalian cell culture
  • Proven scientific track record of publications in reputable scientific journals
  • Commitment to medical sciences
Desirable requirements
  • Previous experience with culturing stem cells and/or organoid systems; application of these systems to study intestinal biology is a particular advantage
  • Experience with flow cytometry and bioinformatics
  • Knowledge of cell signaling pathways
  • Experience working with lab animals
This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based.  The role will be based at Waltham, MA, US with a competitive salary on offer. To apply for this position, go to the AstraZeneca global career site ( https://job-search.astrazeneca.com ) and apply to job R-003877.
If you have previously applied for this position, please Do Not re-apply.
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AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based.  The role will be based at Boston, MA, US with a competitive salary on offer  
If you share our passion for scientific excellence, find out more at careers.astrazeneca.com

A little about us:
MedImmune is the global biologics research and development arm of AstraZeneca

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