Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Postdoctoral Fellow, Oncology with the Translational Research Team, located in Spring House, PA. The duration of the Postdoctoral Fellow program is 2 years.
Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.
The candidate will join a dynamic oncology organization to study therapies that modulate the immune system for the treatment of different types of human malignancies. More specifically, he/she will study the impact of therapeutics that enhance anti-tumor immunity and cause tumor cell destruction, using preclinical mouse tumor models and in vitro assays. The goals of these studies will include characterizing innate and adaptive immune responses in the tumor microenvironment and periphery following treatment with distinct immune therapies (i.e. vaccines and various antibody therapeutics) administered alone or in combination. These studies will also investigate predictive biomarkers of response and mechanisms of resistance to these treatments.
Candidate will have the Experience in mouse tumor immunology and related techniques are strongly preferred.
We are seeking a highly motivated, conscientious and diligent scientist, who is flexible, dynamic, and able to work with autonomy to drive their individual project forward while also contributing to the group as an integral team member. The Postdoctoral Fellow will:
- Collaborate across the oncology and immunology discovery departments at Janssen, as well as with prominent academic labs studying immune modulation in cancer.
- Will design, execute and interpret studies for testing the anti-tumor efficacy of immunotherapies in preclinical tumor models
- Will characterize distinct immune cell populations present in tumor or periphery of treated mice using multi-color flow cytometry
- Will isolate primary mouse immune cells and test functionality in vitro/ex vivo using multiple readouts that include multi-color flow cytometry, MSD/ELISA, cell proliferation, and cellular cytotoxicity
- Demonstrate the ability to work independently and manage multiple experiments simultaneously
- Demonstrate the ability to analyze and present data in professional 'publication ready' format
- Demonstrate the ability to contribute to various projects outside of his/her own, and collaborate within and outside own discovery group and across relevant functions
- Keep up-to-date with the literature related to his/her field.
- Demonstrate clear and professional verbal and written communication
- Candidates must have a recent (0-2 years) or expected Doctorate Degree (e.g., Ph.D) in Immunology, Cancer Immunology or other relevant program is required.
- Experience in design, execution and interpretation of cell based assays/experiments to interrogate functional effects on primary mouse immune cells is required.
- Experience with in vivo models of tumor biology, cytokine expression assays, proliferation assays, and multi-color flow cytometry is required.
- Experience in mouse tumor immunology and related techniques are strongly preferred.
- Experience in vaccines, or the biology of T cells and myeloid cells is strongly preferred.
- Experience in molecular biology including RNA, DNA and protein analysis is preferred.
- This position is located in Spring House, PA. Up to 10% travel may be required.
Johnson & Johnson Companies are equal opportunity employers.
Primary Location: North America, United States, Pennsylvania, Spring House
Organization: Janssen Research & Development, L.L.C
Job Function: PostdoctoralPrimary Location
United States-Pennsylvania-Spring HouseOrganization
Janssen Research & Development, LLC. (6084)Job Function