Postdoctoral Fellow-Structural Biology
Groton, Connecticut
November 17, 2016
Position Type:
Full Time

About the company
A career at the company offers opportunity, ownership and impact.

All over the world, the company colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. the company, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description
The successful candidate will join the department of Structural and Molecular Sciences (SMS), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, NMR, biophysics, protein crystallography and cryo-EM. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to promote discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases, Pain, Rare Diseases and Oncology.

Within the company, we have made a strong commitment to invest in single particle cryo-EM and have set up a state of the art microscope (Titan Krios) with a K2 direct electron detector in newly renovated laboratory, a dedicated computer cluster and a TF20 microscope for screening samples.

As a Postdoctoral Fellow, you will have experience with structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. Ideally you will also be familiar with protein construct design, molecular biology and mutagenesis, protein expression, purification and biochemical/biophysical characterization of a membrane protein.

Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within the company and design suitable experimental strategies based on cryo-EM technique that could positively impact the outcomes. SMS is part of Medicine Design group within the company, with the overall goal of understanding the mode of action of lead compound using an integrated assessment of all aspects of protein-ligand interactions to drive drug discovery efforts.

The Postdoctoral Fellow will design and perform experiments in the technical area of membrane protein purification, characterization and involved in single particle cryo-EM. Experimental results will be formulated computationally and will be recorded in an electronic laboratory notebook.

Prompt and clear communication will occur with project team colleagues. External scientific publication and presentation will be encouraged when appropriate as a means of assuring optimal research standards.

• A PhD or be a PhD candidate (to be completed in 2016) in Biochemistry, Biophysics, Physics, Chemistry or a related field.

• Desire to learn and carry out single particle cryo-EM work with suitable independence, and have the creativity and drive to tackle scientific challenges.


Ability to perform laboratory research and travel.

Other Information - Internal
Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

EEO & Employment Eligibility
the company is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. the company also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. the company is an E-Verify employer.
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