Post-Doctoral Scientist, Oncology Discovery

  • Company: Johnson & Johnson
  • Location: Spring House, Pennsylvania
  • Posted: March 21, 2017
  • Reference ID: 4313170308-en-us

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Post-Doctoral Scientist in Oncology Discovery, located in Spring House, PA. Janssen is the name given to Johnson & Johnson’s global group of pharmaceutical companies.  These companies market both conventional and biotech products in a broad range of therapeutic areas.


The candidate will join a dynamic oncology drug discovery team to study mechanisms involved in stromal cell inhibition of immune responses in the tumor microenvironment. S/he will first characterize inhibitory effects of cancer-associated fibroblasts on the in vitro activity of various immune-regulatory therapeutics. The next step will be to discover the mechanisms by which stromal cells inhibit immune function, and identify specific inhibitory factors and/or interactions.


The Oncology Discovery Post-Doctoral scientist will:

  • Work collaboratively with colleagues in Oncology Discovery as well as with others in immunology discovery, medicinal chemistry, and antibody development groups
  • Be strongly motivated and dedicated; show initiative and troubleshooting skills; and demonstrate the ability to work independently
  • Will design, execute and interpret studies for testing the anti-tumor cell efficacy of immunotherapies in the context of in vitro models 
  • Demonstrate the ability to analyze and present data in professional 'publication ready' format
  • Demonstrate the ability to contribute to various projects outside of his/her own
  • Keep up-to-date with the literature related to his/her field.
  • Demonstrate clear and professional verbal and written communication

  • Candidate will have a PhD with 0-3 years of experience in cancer biology, immunology, or cancer immunology. Expertise in the tumor microenvironment, including the biology of immune cells is strongly preferred.
  • Experience with in vitro models of tumor biology, ELISAs, cytokine expression assays, and proliferation assays is required.
  • Expertise in design, execution and interpretation of cell based assays/experiments to interrogate functional effects on the tumor microenvironment is required.
  • Expertise in molecular biology including RNA, DNA and protein analysis is preferred. Experience with flow cytometry is preferred.
  • Experience in designing and interpreting in vivo efficacy models is preferred.


Primary Location
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID

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