Sr. Scientist, Computational Sciences

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist to join the Computational Sciences group within Discovery Science, to be based out of Cambridge MA or Springhouse PA. Up to 10% domestic and international travel is required.


At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 


Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.  


We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.


Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer. 


The candidate will join the Computational Sciences group within Discovery Science, to develop and implement cutting-edge analytical approaches across –omic datasets to aid in target identification, validation, pathways of drug resistance and synthetic lethality, and mode of action studies to support the identification of small and large molecule therapeutics for disease indications listed above. Analysis of genome scale functional genomic screens will be a cornerstone of the effort, and understanding how to integrate other appropriate –omic datasets will be key. S/he will work in an exciting, interdisciplinary environment, overlapping the different stages of drug discovery, and interacting with several internal and external groups. The candidate should be highly self-motivated and able to work independently. Responsibilities for the candidate will include, assisting in the design of cellular experiments and screens using shRNA, CRISPR/Cas9, and other functional genomics screens. Moreover, the candidate will drive the analysis of screening data in combination with large clinical data sets, RNAseq, CHIPseq, proteomic, metabolomic, and other types of metadata. The candidate is expected to be able to communicate his/her results to a team of diverse backgrounds in a clear and efficient manner. S/he should demonstrate a sense of urgency, be organized and adhere to sensitive timelines.

  • Aid in design screen parameters for statistical power.
  • Interpret and perform QC analysis on functional genomics data.
  • Analyze pooled genome scale functional genomics screens from both in vitro or in vivo experiments.
  • Integrate additional data to increase confidence of hit calling from functional genetic screens.
  • Act as a subject matter expert in her/his scientific field and related disciplines.
  • Propose novel and actionable analytic ideas, aligned with internal and external scientific strategies and demands
  • Manage multiple experiments and projects simultaneously
  • Collaborate with stakeholders and business partners from all relevant functions and contribute to various projects within the organization
  • Communicate in a clear and professional manner, both in writing and orally

  • Ph.D. degree with 8+ years of productive post-doctoral experience in a high-quality academic, biotech or pharmaceutical environment
  • Previous experience analyzing pooled genome scale functional genomics screens is required
  • Previous experience integrating other appropriate –omic datasets is required
  • Drug discovery experience in a biotech or pharmaceutical environment is a plus. 
  • Strong organizational skills including the ability to manage several projects simultaneously
  • Demonstrates creativity and novel approaches to solving scientific problems
  • Strong record of publications is required
  • Detail-oriented, with excellent record-keeping skills
  • Able to effectively present scientific data and concepts to international standards.

Primary Location
United States-Massachusetts-Cambridge
Other Locations
North America-United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)
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