Principal Scientist/Associate Director of Translational Science, Oncology
Waltham , Massachusetts
October 20, 2017
At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a Principal Scientist/Associate Director of Translational Science in Waltham, MA, you'll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients' lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas.
AstraZeneca's vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the aim of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers. As well as other tumour types, these are being targeted through four key platforms - immunotherapy, the genetic drivers of cancer and resistance, DNA damage repair, and antibody drug conjugates, underpinned by personalised healthcare and biomarker technologies.
Main Duties and Responsibilities
We are seeking a Principal Scientist/Associate Director in Oncology Translational Science to join a world class center for discovery and development of innovative cancer medicines.  Based in Waltham, MA you will be accountable for delivery of robust, scientifically-driven biomarkers in drug discovery and development programs.  You will have the opportunity to impact an industry-leading portfolio of targeted therapy programs from inception through to life cycle management for marketed drugs. 
In this role you will develop biomarker strategies and ensuring delivery within oncology project teams.  You will deliver biomarkers for clinical studies based on the best available science and technologies.  You will generate disease linkage data to guide indication selection and targeted patient populations.  You will measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.  You will understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.  You will define novel mechanisms of resistance targeted therapies by studying tumors at relapse.
Essential Requirements
  • PhD with 5-10 years experience or equivalent experience within industry
  • In-depth knowledge of disease area biology and translational science
  • Proven communication and influencing skills
  • Highly developed problem solving and risk management skills
  • Highly developed collaborative working skills
  • Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca,
  • Proven ability to motivate and develop others
Next Steps - Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

A little about us:
At AstraZeneca, we believe the best way we can help patients is to focus on breakthrough science in order to uncover disease mechanisms and develop novel, targeted therapies that interact with them. This is at the heart of our purpose as a company: to push the boundaries of science to deliver life-changing medicines.

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