Principal Scientist/Director and Team Leader, Oncology Bioscience

  • Company: AstraZeneca
  • Location: Waltham, Massachusetts
  • Posted: December 01, 2017
  • Reference ID: R-017957
Principal Scientist/Director and Team Leader, Oncology Bioscience - Target identification/validation and early project leader
At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.
As the Principal Scientist/Director and Team Leader, you must be a highly motivated PhD scientist with extensive knowledge in cancer biology and a proven track record of innovation in genetics and molecular biology to lead a team accountable for target ID/validation and delivery of drug discovery projects in Waltham, MA.  We routinely apply RNAi, CRISPR/Cas9 and other genome editing techniques and screening approaches to validate and discover novel oncology targets, with the ultimate goal of identifying a clear path forward in delivering breakthrough therapies to benefit cancer patients.  
Based in Waltham, MA and reporting to the Executive Director of US Bioscience, you will lead a team to utilize existing genetic tools as well as novel technologies and approaches in the target ID/validation space to shape the early drug discovery portfolio and influence the Global Oncology strategy.  Strong analytical, problem-solving skills and working knowledge of bioinformatics strategies/tools to support target discovery are essential since you will ultimately be responsible for systematically interrogating a wide range of proposed targets with support from various functional groups e.g. Oncology Bioinformatics and Discovery Sciences.  Strong organizational, communication, teamwork, and people management skills are also highly desired to effectively manage the local team as well as to identify and liaison with external academic and industry groups.
Preferred Background:
Ph.D. in genetics, biochemistry, molecular biology, cell biology or related field 10+ years of oncology drug discovery & target validation experience in a Pharma/Biotech setting Strong team leading, organizational, communication, and listening skills
Capable of bringing people with different scientific backgrounds together to work towards a common goal
Demonstrated success in mentoring team members
Experience in leading successful collaborative projects
Strong publication record & analytical skills Experience in leading and delivering drug discovery programs focused on genetic tumor drivers and/or resistance is a plus
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Next Steps - Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

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