Scientist, DMPK

  • Company: Johnson & Johnson
  • Posted: August 17, 2016
  • Reference ID: 1631160325-en-us

Janssen Research & Development, LLC, a Johnson and Johnson Company, is hiring a Scientist, DMPK to be located in La Jolla, CA.

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.  

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. We are proud to be an equal opportunity employer.

The Scientist, DMPK will:
  • Support drug discovery and early development efforts as a member and representative of the PDM (Pharmacokinetics, Dynamics and Metabolism) group working closely with other teams such as chemistry, biology, and toxicology.
  • Manage and/or conduct in vitro ADME studies using various matrices (e.g. liver microsomes, hepatocytes, blood/plasma).
  • Design and execute mechanistic experiments tailored to address project specific questions such as characterizing enzyme kinetics, investigating non-P450 metabolism (e.g. UGT- or AO-metabolism) and measuring tissue binding.
  • Perform bioanalytical method development and quantitation of discovery compounds in blood or tissue of preclinical species.
  • Develop and implement new assays. 

  • A BS or MS degree in Pharmaceutical Sciences or a related field with at least 8 years of relevant pharmaceutical industry experience is required.
  • Understanding of DMPK principles, experience in outsourcing and conducting various ADME assays and strong technical expertise in bioanalysis using LC-MS/MS systems (ABI Sciex) are required. 
  • Experience as a DMPK project team representative is a plus. 
  • The candidate must possess excellent interpersonal, organizational, oral/written communication and leadership skills.  
  • The position is located in La Jolla, CA and may require up to 10% travel.

Primary Location
United States-California-San Diego
Janssen Research & Development, LLC. (6084)
Job Function

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