Scientist, HTS Assay Design, Development, and Execution
Location:
Spring House , Pennsylvania
Posted:
April 02, 2017
Reference:
8251170126-en-us

Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Scientist, HTS Assay Design, Development and Execution, to be located in Spring House, PA. 

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 


Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information. 


The new Lead Discovery team is a critical part of the Discovery Sciences organization in Janssen R&D and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area discovery teams.  This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.


The Screening department within Lead Discovery is responsible for the delivery of small-molecule qualified hits for the initiation of hit-to-lead programs within the Therapeutic Areas.   Major activities include HTS assay development, screening, and pharmacological profiling.  The Screening Team collaborates closely with Janssen Therapeutic Areas and functional teams, the Innovation Centers, and external collaborators in academia and industry.  We seek individuals with a strong ability to connect key stake holders for the delivery of goals and objectives, fostering an environment of collaboration, collegiality and positive communication, and who show superior performance in the context of a multidisciplinary, geographically disperse team. 

 
 
Roles and Responsibilities

Lead the design and implementation of screening strategies to target the specific pharmacology of hit-to-lead discovery programs.


Perform laboratory experiments to design, optimize, and miniaturize biochemical and cell based assays that are suitable for automated high-throughput screening in 384 or 1536-well formats.


Write and review protocols for high-throughput screening and compound profiling assays.


Analyze, interpret, and publish large data sets using GeneData and Spotfire.


Present experimental observations and conclusions at program team meetings.

Develop innovative approaches to screening and hit triage, using combinations of enzymology, biophysics, and cell biology tools.


Attend in-house seminars and external scientific meetings as appropriate.


Publish research in high-quality journals as appropriate.



Qualifications
  • PhD and postdoctoral experience in biochemistry, enzymology, molecular pharmacology or related areas is required.
  • Expertise in biochemical and/or cell biology assay development and data analysis is required
  • Experience in characterization of enzyme targets and protein-protein interactions is desired
  • Expertise in any of the following is desired:

Radiometric assays, Fluorescence Polarization, HTRF, SPR, Microscale Thermophoresis.

  • Publications in high-quality peer-reviewed journals is required.
  • Excellent written and oral communication skills is required.
  • Expertise in cardiovascular, immunology, infectious diseases, neuroscience or oncology therapeutic areas is desired.
  • Experience working with and guiding external collaborators in industry or academia is desired.
 


Primary Location
United States-Pennsylvania-Spring House
Organization
Janssen Research & Development, LLC. (6084)
Job Function
R&D
Requisition ID
8251170126

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