Scientist, HTS Assay Development

Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Scientist, HTS Assay Development, to be located in Spring House, PA. 

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. 

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The new Lead Discovery team is a critical part of the Discovery Sciences organization in Janssen R&D and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area discovery teams. This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.

The Screening department within Lead Discovery is responsible for the delivery of small-molecule qualified hits for the initiation of hit-to-lead programs within the Therapeutic Areas. Major activities include HTS assay development, screening, and pharmacological profiling. The Screening Team collaborates closely with Janssen Therapeutic Areas and functional teams, the Innovation Centers, and external collaborators in academia and industry. We seek individuals with a strong ability to connect key stake holders for the delivery of goals and objectives, fostering an environment of collaboration, collegiality and positive communication, and who show superior performance in the context of a multidisciplinary, geographically disperse team.

Roles and Responsibilities
• Lead the design and implementation of screening strategies that reflect the pharmacology to be modulated in subsequent hit-to-lead discovery programs.
• Develop assays in cell-based and biochemical formats that are suitable for automated high-throughput screening in 384 or 1536-well formats.
• Perform high-throughput screens.
• Analyze and publish screening data including presentation at program team meetings.
• Develop innovative approaches to screening and hit triage using, for example, 3D cell culture, co-culture, high-content imaging, phosphoprotein profiling or gene expression profiling.
• Attend in-house seminars and external scientific meetings as appropriate.
• Publish research in high-quality journals as appropriate.

• PhD and postdoctoral experience in cell biology, biochemistry, molecular pharmacology or related areas is required.
• Expertise with cell-based assay development is required.
• Expertise with methods such as luminescence, fluorescence, absorbance and radiometric detection in plate-based format is desired.
• Publications in high-quality peer-reviewed journals are required.
• Excellent written and oral communication skills are required.
• Expertise with 3D cell culture and/or co-culture of multiple cell types including iPS-derived cells is desired.
• Expertise with protein or gene expression profiling is desired.
• Expertise in cardiovascular, immunology, infectious diseases, neuroscience or oncology therapeutic areas is desired.
• Experience working with and guiding external collaborators in industry or academia is desired.
• Experience with membrane receptor pharmacology and physiology, including ion channels, G-protein Coupled Receptors (GPCRs) and/or transporters is desired.

Primary Location
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID

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