Scientist I/II - Protein Formulation Development

  • Company: MedImmune
  • Location: Gaithersburg, Maryland
  • Posted: July 20, 2017
  • Reference ID: R-010938
If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Scientist I/II - Protein Formulation Development in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.
Main Duties and Responsibilities
This position is a Scientist level role that supports formulation development activities of novel protein-based molecules (fusion proteins/bispecifics/antibody drug conjugates/peptides) and monoclonal antibody molecules in early-stage (research to late phase 2) clinical development. Formulation development activities include stability testing and characterization of routes of degradation of proteins in liquid and lyophilized formulations under accelerated temperature, refrigerated storage conditions and under agitation and freeze-thaw stresses in a variety of containers. Analytical methods that are used routinely include HPLC (reversed-phase HPLC, size-exclusion chromatography, ion-exchange chromatography), UV-visible spectroscopy, HIAC and MicroFlow Imaging sub-visible particle counting. Biophysical instrumentation (differential scanning calorimetry, titration calorimetry, fluorescence, circular dichroism) will occasionally be used for protein structural characterization. Activities to support Drug Product manufacturing will be performed, including tech transfer and on-site visits to CMOs (contract manufacturing organizations).
Candidate will work under general supervision of a manager and will supervise other scientists and associates.  The candidate will Independently plan, design, and execute formulation development projects, typically more than one project at a time. Candidate will make detailed observations, analyze data, and interpret results and develop research findings and make recommendations, and demonstrate scientific rigor in assessing their own data and that of others. Candidate will maintain a high level of expertise through review of current scientific literature, submissions to scientific journals, and attendance and participation at conferences focused on the research and development efforts of the company. Candidate will also present data and results at group and department meetings and contribute to the preparation of scientific manuscripts and patent applications. The individual should be familiar with and be able to follow Standard Operating Procedures (SOPs) for experimental operation and data recording.
Responsibilities include participation and leadership of one or more project teams and research initiatives that are related to formulation science of proteins and novel molecules in the MedImmune pipeline.
Essential Requirements
Scientist I: PhD, MS or BS in Chemistry, Biochemistry, Pharmaceutical Chemistry, Bioengineering or a related field with 0-3 years (PhD) or 8-10 years (MS) or 10-13 years (BS) experience in the pharmaceutical industry as appropriate (biotechnology area preferred).
Scientist II: PhD, MS or BS in Chemistry, Biochemistry, Pharmaceutical Chemistry, Bioengineering or a related field with 3-7 years (PhD) or 10-13 years (MS) or 13-15 years (BS) experience in the pharmaceutical industry as appropriate (biotechnology area preferred).
  • Candidate must be able to independently plan design and execute experiments and apply effectively chemistry, biochemistry and pharmaceutical knowledge and principles to the design and execution of laboratory experiments.
  • Candidate will be expected to contribute to and provide solutions to technical problems and think creatively. Experience with protein/peptide formulation and characterization, lyophilization, SEC, UV-vis spectroscopy and HPLC are required.
  • Additional experience with the above biophysical techniques is a plus but not required.
  • This is also a laboratory-based position and the candidate must be familiar with laboratory operations (weighing chemicals, balance operation, pH measurement, buffer preparation, lab safety) while adhering to established procedures.
  • Candidate must have strong interpersonal, communication and presentation skills and the ability to thrive in a fast-paced dynamic environment.
  • Good verbal and written communication skills, attention to detail and organized work habits are essential.
Next Steps - Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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