ROLE SUMMARY Recent advances in functional genomics technologies have led to unprecedented opportunities to deepen our understanding of disease biology, screen for new drug targets, and validate candidate targets arising from genetic association and other studies. As integral part of Pfizer Worldwide Research and Development our Functional Genomics group works to establish and apply experimental tools including screens for examining gene function, in order to bring the best targets into the Oncology Research Unit's portfolio and deepen our knowledge of targets under development. We are seeking a highly motivated and pro-active cancer biologist or immunologist, with expertise in flow cytometry and gene modulation technologies (shRNA/CRISPR), to contribute to the success of the Functional Genomics laboratory in Pearl River, NY. This is an exciting opportunity to apply cutting-edge methods and contribute with our team to the target portfolio of one of the world's leading developers of novel therapeutics. ROLE RESPONSIBILITIES • Careful planning, independent execution, trouble-shooting, as well as data analysis support of day- to multi-week-long experiments to test the functional consequences of genetic variants and pharmacologic agents in cell-based model systems, using co-culture systems and cell engineering methods that include lenti-/retroviral transduction and CRISPR-based gene editing technologies. • Perform cutting-edge genomic and phenotypic CRISPR-based screens to identify new targets in immuno-oncology using advanced murine and human cell culture and transplantation systems. • Assist with the evaluation of new approaches and pro-actively introduce improvements to the offerings of the Functional Genomics group. • Work and communicate closely with other Pearl River colleagues and support interaction with our Oncology Research Unit partner sites in San Diego (La Jolla) and the Bay Area (South San Francisco). • Present research results and discuss methods at weekly/monthly group meetings. QUALIFICATIONS • Bachelor's or Master's degree in immunology, cancer cell biology, or related field with substantial experience in multi-color flow cytometry required. Experience in cell sorting, functional genomic screens, and CRISPR-based gene editing or RNA interference technologies of advantage. • At least 6 years of laboratory experience and continuous scientific curiosity in an industrial or academic setting, preferably in an immunology or cancer immunobiology group. • Demonstrated expertise with antibiotic-free isolation, culture, and genetic manipulation of primary immune cells for advanced assays including mixed-cell in vitro systems and multifactorial readouts, e.g., phenotypic changes, proliferation, activation, target cell killing and production of soluble factors. Proficiency in a variety of molecular biology methods, including cloning, expression analysis, and next-generation DNA/RNA sequencing. • Track record of contributions to successful research projects. Experience with in vivo transplantation systems, liquid handling, and/or high content imaging a plus. • Ability to effectively and positively interact and collaborate with other scientists, both within the group and together with other groups; excellent communication and interpersonal skills essential. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. 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If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. Additional Offer Details: Grade: 6 Eligible for Employee Referral Award A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.