Senior Associate Scientist, AAV Cell Based Assays
Cambridge , Massachusetts
November 22, 2017

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. The Gene Therapy Translational Sciences group located in Cambridge, MA is part of Pfizer's Rare Disease Research Unit (RDRU) with a focus on gene therapy specific platform technologies towards the delivery of IND-approved vectors for testing in clinical trials. This bench Sr. Associate Scientist will be part of an interdisciplinary team and contribute to preclinical data required to advance Pfizer's gene therapy-based portfolio. This Sr. Associate Scientist will be part of an interdisciplinary team and contribute to preclinical data required to advance Pfizer's gene therapy-based portfolio. This particular role will have a strong focus on performing screening assays for the presence of the neutralizing antibodies to AAV capsid as well as other cell based assays in support of AAV vector characterization. Sr. Assoc. Sci will make significant technical contributions under moderate supervision by using established methodologies. Sr. Assoc. Sci will be encouraged to reduce to practice novel technical approaches. MAIN RESPONSIBILITIES Perform cell based assays aimed at characterization of AAV gene therapy vectors, including RC AAV, TCID50, potency and other assays. Produce small scale research vector preps with the oversight of the more senior scientist. Execute experiments, analyze and interpret data, deliver high-value data reports to Gene Therapy projects in the RDRU pipeline. Perform neutralizing antibody assays on human and animal serum samples. Partner with RDRU biology group and other disciplines of integrated drug discovery and development, especially pharmacokinetics and drug disposition, to help prepare translational preclinical packages for gene therapy clinical candidates. Support aspects of internal and external collaborations and contracted projects. BASIC QUALIFICATIONS Bachelor's Degree in the life sciences with 2-4 years of academic or industry research experience or Master's Degree in the life sciences with 0-2 years of academic or industry research experience. Scientific background in biology, molecular biology, or cell biology Experience with cell based assays is required. Experience with AAV vectors is required Experience with cell banking is highly desired. Exceptional communication skills and demonstrated ability to work effectively as part of a team Evidence of scientific accomplishments in the form of publications and presentations preferred ADDITIONAL OFFER DETAILS Last Date to Apply for Job: December 5, 2017 This job is Pfizer Exempt US/PR Grade: 004 Additional Location Information: Cambridge, MA (Kendall Square) Relocation Package Available: Yes EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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