Senior Associate Scientist, Formulation
Location:
Andover , Massachusetts
Posted:
November 22, 2017
Reference:
411644999

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. This position will be part of Pharmaceutical Research and Development. The incumbent will participate in the development of parenteral formulation for biologics modalities such as monoclonal antibodies, antibody drug conjugates, proteins, vaccines, cell-based therapies and viral vectors for genomic therapeutics. This position will be responsible for performing analytical characterization of candidate molecules by using various biophysical and biochemical characterization techniques. Furthermore this position will assist in developing processes for drug product manufacturing, responsible for data compilation, data presentations and report writing. ROLE RESPONSIBILITIES The responsibilities of the Senior Associate Scientist position include but are not limited to : Participate in developing parenteral formulations for biotherapeutic modalities such as monoclonal antibodies, antibody drug conjugates, proteins, vaccines, cell-based therapies and viral vectors for genomic therapeutics. This position will be responsible to assist in developing manufacturing processes (under general supervision). Perform rapid, comprehensive characterization of candidate molecules to determine the stability profile and applying this information to develop an appropriate dosage form to meet clinical needs. This will be achieved by applying various biophysical and biochemical techniques such as HPLC (SE-HPLC, IEX, RP-HPLC), SDS-PAGE, Capillary Gel electrophoresis (CGE),imaged Capillary Electrophoresis (iCE), Spectroscopy techniques such as UV and Fluorescence spectroscopy, Circular Dichroism and FTIR. The incumbent will assist in the development and scale-up of drug product processes from bench top to pilot scale and, as required, technology transfer to commercial plants. Examples of drug product processes are fluid transport, sterilizing filtration and lyophilization. The Senior Associate Scientist must be able to interact effectively with a multi-disciplinary team of scientists for formulation optimization and overall candidate progression. This position will be responsible for preparing data summary presentation, compiling data and authoring technical reports. Effective communication skills are desirable for interactions with laboratory scientists, project managers and colleagues from numerous functions, serving on multi-disciplinary project teams. BASIC QUALIFICATIONS Bachelor's Degree in Pharmaceutics, Chemistry, Chemical/Biochemical Engineering, Pharmacy, Biochemistry or equivalent with 2-4 years of experience Industry experience in parenteral formulation and process development of protein/peptide/vaccine therapeutics. Experience with biotherapeutics analytical methods such as HPLC (SE-HPLC, IEX, RP-HPLC), SDS-PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), spectroscopy techniques Demonstrated scientific documentation skills PREFERRED QUALIFICATIONS Master's Degree in Pharmaceutics, Chemistry, Chemical/Biochemical Engineering, Pharmacy, Biochemistry or equivalent with 0-2 years' experience Knowledge of drug development processes for progression of a biological candidate. Familiarity with GMP requirements. Familiarity with parenteral manufacturing requirements, container/closure integrity, and commercial unit operations. Practical knowledge of lyophilization and lyophilization cycle development is preferred. Familiarity in scale-up and technology transfer to pilot/commercial scale. ADDITIONAL OFFER DETAILS Last Date to Apply for Job: January 9, 2018 This job is Pfizer Exempt US Grade: 004 Additional Location Information: Andover, MA EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


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