The T cell Immuno-Oncology (I-O) group in Pfizer is building a world-class immunology team and is seeking a highly motivated and creative Senior Principal Scientist to join a group of researchers evaluating novel therapies in the fields of Cancer Immunotherapy, Immune Checkpoint Biology, and Innate Immunity. The candidate will report to the Director, Cancer Immunology and work closely with other disciplines across Pfizer to drive early discovery research programs into early clinical development, providing scientific and technical leadership. Specifically, the candidate will identify unique tumor-specific micro-environmental cues that impact T cell function, differentiation and trafficking using a variety of tools including, classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models. Responsibilities: Supervise research associates and/or scientists. Discover and develop new therapeutic modalities for cancer immunotherapy. Independently design and perform studies to evaluate the anatomical distribution, persistence and function of antigen-specific T cells in preclinical models of cancer. Explore disease mechanisms and mechanism of drug action in vitro and in vivo. Collaborate with protein engineering, computational biology, T cell redirecting therapy group and clinical development group to pursue the most promising drug candidates through clinical trials. Participate in collaboration on novel I-O targets with internal and external collaborators. Present at group meetings, global project team meetings, and site meetings. Education and Experience Ph.D. in Immunology with 8+ years of experience in T cell and or dendritic cell biology. Strong understanding of tumor immunology. In-depth understanding of: T cell biology and/or Dendritic cell Biology Inhibitory and co-stimulatory molecules and their associated signal transduction pathways. Solid technical knowledge and hands-on experience with conventional immunological techniques. Broad experience in assessing T cell function, differentiation, and memory development. Experience in immune cell isolation and characterization using multi-color flow cytometry. Working knowledge of various murine tumor and/or infectious disease models. Ability to evaluate and recommend new therapeutic concepts in the area of immune modulation. Ability to supervise, mentor and develop research associates and scientists. Pro-active attitude and strong desire to discover novel biology and potential new drugs. Strong oral presentation and communication skills. 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