Senior Research Associate II, DMPK Translational Research
Location:
San Diego, California
Posted:
August 26, 2016
Position Type:
Full Time
Category:
Research
Reference:
1601888
OBJECTIVES:
  • As a member of Drug Metabolism and Pharmacokinetic (DMPK) Translational Research group at Takeda, you will participate in drug discovery and development through development and execution of quantitative biomarker assay development
  • Primary duties to be performed under minimal supervision are to:
    • Design and execute assays to quantify proteins, peptides and antibodies to support TCAL projects 
    • Develop analytical methods and conduct quantitative analysis of biomarkers in study samples independently
    • Conduct data interpretation and reporting of study results and conclusions

ACCOUNTABILITIES: 
  • Design, execute and report key biomarker data to support portfolio
  • Evaluate and develop fit-for-purpose biomarker assays via LC-MS/MS technologies, ligand-binding assays, or other appropriate assay systems
  • Prepares protocols for and conducts routine sample preparation and analysis of serum and/or tissue samples
  • Will assist in preparation of technical reports or summaries.
  • Evaluate new techniques, technologies and equipment (LC-MS/MS, FACS, etc).
  • Assists in the implementation of new methods and processes.
  • Participates in the interpretation of scientific data.
  • With some guidance, plans, conducts, evaluates and interprets non-routine laboratory experiments.
  • Remains current with new practices and procedures in relevant literature.
  • Provides solutions to a variety of problems of moderate scope and complexity.
  • Collaborates and communicates within and across departments.
  • Responsible for maintaining accurate records of ongoing projects in a laboratory notebook.
  • May contribute to authorship of technical reports, manuscripts or posters.
  • May present data to cross-functional project team; may present data/posters at external or internal conferences.
  • Follow company safety procedures.
  • Maintains lab equipment and supplies as necessary.

Qualifications EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: 

  • Qualified candidates will have experience in the pharmaceutical or biotech industry with hands-on experience with conducting bioanalysis of proteins, peptides and/or antibodies from human and animal derived tissues and biological matrices
  • BS/MS in Pharmaceutical Sciences/Chemistry/Biochemistry/Biology or related coursework and 8+ years of relevant experience or MS with 6+ years of relevant experience.
  • Experience in the development and validation of LC/MS assays for the quantitation of proteins and/or peptidesin industry.
  • Experience in multiple techniques applicable to quantitative measurement of proteins, peptides and/or antibodies for pharmacokinetic and/or pharmacodynamic analysis, including ECL (Meso Scale Discovery Platform or similar), LC/MS, etc.
  • Ability to identify and implement (where and when appropriate) new technologies for the advancement of quantitative biomarker analytics
  • Experience with bioanalysis using cell-based assays (binding/bioassays) a plus
  • Experience with SoftMax Pro software, MSD Discovery Workbench, and Bioanalytical LIMS ( such as Watson-LIMS and/or StatLIA)

  • Skilled and proficient at making detailed observations, analyzing data, and interpreting results so as to be able to suggest, design and pursue relevant experiments
  • Experienced in reporting study results for internal decision making
  • Demonstrated ability to solve scientific problems creatively, effectively and independently
  • Willing to assist with DMPK department objectives in general
  • Good  written and oral communication skills
  • Good multitasking skills

LICENSES/CERTIFICATIONS:
  • None 

PHYSICAL DEMANDS: 

  • Manual dexterity required to operate standard laboratory and office equipment    
  • Carrying, handling and reaching for objects
  • Exposure to hazardous/toxic/dangerous chemicals
  • Prolonged standing and/or sitting.

TRAVEL REQUIREMENTS:

  • Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.

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Schedule
Full-time
A little about us:
Takeda fosters an inclusive environment where all employees are empowered, supported and inspired to use their unique talents toward our mission to serve patients.

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