Janssen Research & Development, L.L.C., a
Johnson & Johnson company, is recruiting for a Senior Scientist,
Computational Biology, Translational Research to be located in Spring House,
Janssen R & D, LLC
discovers and develops innovative medical solutions to address important unmet
medical needs in oncology, immunology, neuroscience, infectious diseases and
vaccines, and cardiovascular and metabolic diseases. Please visit
http://www.JanssenRnD.com to learn more.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
In this role you will:
- Provide data analysis
and Computational Biology support for the Oncology therapeutic area, working in
close collaboration with scientists in Translational Research, Discovery,
Clinical Development, and Discovery Sciences to analyze, integrate, and
interpret high dimensional data from a variety of platforms including
next-generation sequencing, gene expression microarrays, SNP, RBM, and IHC.
- Provide oncology data
analysis and computational biology support to identify disease mechanisms,
mechanism of action for therapeutic interventions, and candidate biomarkers for
the Oncology TA.
- Build, analyze, and
interpret biological networks from disparate data sources. He/she will also
collaborate with R&D IT to implement informatics systems that address the
Oncology TA needs.
- Perform real-time
bioinformatics and statistical analysis, visualization, and data interpretation
for Oncology Disease Area Strongholds (DAS) using statistical and machine
learning methods to identify prognostic and predictive biomarker signatures
from high dimensional biological data.
- Employ strategies
integrating data from external (e.g. NCBI Entrez, NCBI GEO, TCGA/ICGC, UCSC
Genome Browser, GeneGo, Ingenuity) and internal sources, including clinical
- Evaluate and develop
novel algorithms and approaches for data analysis.
- Analyze complex
datasets to support Oncology Discovery, Translational Research, and
Experimental Medicine and communicate results to bench scientists, clinicians,
and management in an appropriate biological context.
will also participate in Disease Area Stronghold meetings and proactively support
related Bioinformatics and Computational Biology projects.
The candidate will
maintain compliance with all internal requirements
for data integrity and reproducible research, actively interface with the
internal and external scientific and technical community, and participate in
technology evaluations and software/database usage training.
Master’s Degree in Computational Biology, Biostatistics or related field with a minimum of 4 years of relevant experience working on bioinformatics projects
a Ph.D. in Bioinformatics, Computational Biology, Biostatistics or related
field with 2 years postdoc or industry experience working on bioinformatics
- Prior work experience in a computational biology,
bioinformatics or related setting.
- Experience in one or more of the
following: high dimensional data integration, gene expression
analysis, next generation sequencing analysis, survival analysis, and/or
biological network inference.
- Strong R programming skills.
- Working experience in Unix/Linux environment.
- Ability to travel as needed (approx. 10%)
- Proficiency with classification and machine
- Statistical analysis experience with working
knowledge of regression analysis, multivariate data analysis, and
linear/nonlinear mixed effects modeling.
- Experience with BioConductor.
language experience (e.g. Perl or Python).
- Other high level programming (Java, C++,
etc.) and database (e.g. MySQL, PostgreSQL, Oracle) experience .
- Oncology experience.
- Biological background.
United States-Pennsylvania-Spring HouseOrganization
Janssen Research & Development, LLC. (6084)Job Function