Principal Scientist, DMPK Translational Research
Location:
San Diego , California
Posted:
September 21, 2017
Reference:
1601891


Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Principal Scientist, DMPK Translational Research in our San Diego office.




OBJECTIVES:

  • Principal scientist with demonstrated scientific and technical leadership in quantitative biomarker assay development. As a Principal Scientist in the Drug Metabolism and Pharmacokinetic (DMPK) Translational Research group at Takeda, you will serve as a functional leader and be responsible for providing input into research strategies , and collaborating with global Takeda sites for the advancement of the portfolio, translational medicine and pre-clinical biomarker efforts for programs to IND filing. Additionally, it is expected that the individual will provide scientific and technical leadership in quantitative biomarker assay development and execution, oversee and manage translational research activities within the DMPK department, and develop and mentor DMPK team members. The individual will work cross functionally to develop and integrate translational research into project strategy to maximize value of Takeda California (TCAL) drug discovery programs. Ensures selection and utilization of appropriate in vitro, in vivo, ex vivo and in silico methods and models to enable human dose prediction and build confidence in target selection, candidate selection and clinical development.
  • In this position, the individual is expected to demonstrate strong written and oral communication, technical proficiency, scientific creativity, and to think and work independently. The role consists of laboratory-based activities as well as providing input into research strategies to matrix teams and/or program teams and will collaborate with global Takeda sites for the advancement of the portfolio, translational medicine and pre-clinical biomarker efforts for programs to IND filing.
ACCOUNTABILITIES:
  • Support drug discovery and early development programs by providing relevant scientific and strategic input with respect to quantitative analytics of biomarkers, PK-PD, and translational research strategy.
  • Accountable for the design, execution, and reporting of key biomarker data to support compound progression and translational research strategy for programs from target loading through early clinical development
  • Work with cross-functionally with TREC and DDUs to deliver translational research strategy, including non-clinical and clinical biomarker strategy, through candidate selection
  • Collaborate with biology, pharmacology, and modeling and simulation colleagues to design and conduct PK/PD and/or efficacy studies to support translation and clinical dose setting
  • Evaluate and develop biomarker assays via LC-MS/MS technologies, ligand-binding assays, or other appropriate assay systems
  • Contribute equally with other project team members on high level project strategy
  • Work closely with department colleagues to coordinate work for project teams
  • Is responsible for ensuring strong alignment and interfaces with DMPK and TREC groups across US affiliates and Japan Discovery and Development
  • Keep an accurate notebook according to company policy
  • Communicate with colleagues effectively
  • Follow company safety procedures




Qualifications:



EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:

  • PhD in Pharmacology/Biochemistry /Life Science/Engineering or related coursework with 8 + years of relevant experience, or MS/MA with 18 + or BS/BA with 20 + years experience. Supervisory experience is highly preferred.
  • Expertise in developing fit-for purpose biomarker assays for the measurement of proteins, peptides, and antibodies
  • Expertise in development of quantitative analytical bioassays from complex matrices is required
  • Thorough understanding of application of biomarkers to understanding exposure-effect relationships.
  • Ability to identify and implement (where and when appropriate) new technologies for the advancement of quantitative biomarker analytics
  • Must be able to manage assay development and analysis queues and timelines
  • Knowledge of drug discovery process, DMPK function and pharmacology is required
  • Demonstrated ability to solve scientific problems creatively, effectively and independently
  • Demonstrated ability to work within a matrix and team environment
  • Excellent oral and written communication skills
LICENSES/CERTIFICATIONS:
  • None required

PHYSICAL DEMANDS:
  • Manual dexterity required to operate standard laboratory and office equipment
  • Carrying, handling and reaching for objects
  • Exposure to hazardous/toxic/dangerous chemicals
  • Prolonged standing and/or sitting.
TRAVEL REQUIREMENTS
  • May travel to various domestic conferences or client sites, including overnight trips
  • Some international travel may be required
  • Requires a minimum of 2% travel


TRAVEL:
  • Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
  • Requires approximately 10-30 % travel.


WHAT TAKEDA CAN OFFER YOU:
  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx



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