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The Department of Pharmacology at Merck Research Laboratories is seeking a Senior Scientist to join a group of researchers dedicated to the discovery of novel anti-infective drugs. The primary responsibilities of the group are to design, develop, and execute in vitro assays to evaluate and characterize drug candidates from antibacterial, antifungal, antiviral and/or vaccine development programs.
The successful candidate will:
- Develop and execute novel in vitro assays to assess inhibition of viral, bacterial, or fungal growth by small molecules and/or biologics, and in vitro assays in support of vaccine development
- Validate and integrate new technologies or methodologies, as needed, to address questions related to drug discovery programs and projects
- Optimize efficiency and productivity through effective management of work flow
- Evaluate outsourcing options and design work plans as appropriate
- Represent Pharmacology on program teams and provide input on the design of the program's research operating plan and strategy
- Ensure timely communication and delivery of high-quality in vitro data to Therapeutic Area program teams
- BA/BS in biology, biochemistry, virology, bacteriology or related discipline and five years of experience post-graduation, or PhD in biology, biochemistry, virology, bacteriology or related discipline and 2 years of experience post-graduation
- Ability to understand and implement applicable regulations regarding the use of pathogens (e.g. virus, bacteria, fungi), human cell and tissue use, laboratory safety, health physics and chemical hazards in research.
- Experience in the design, development and execution of in vitro assays for anti-infective drug development programs targeting antivirals, antibacterials, antifungals, and/or vaccines
- Strong collaborative skills
- Skill in troubleshooting experimental design, assay development and data analysis
- Experience in assay development in support of antibacterial, antifungal drug discovery
- Experience in antiviral drug discovery, supporting vaccine development
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