Senior Scientist, Protein Engineering

  • Company: Pfizer
  • Location: South San Francisco, California
  • Posted: December 08, 2017
  • Reference ID: 1620645

The Protein Engineering Department is seeking an outstanding Senior Scientist to lead protein engineering and technology development projects. The candidate will be responsible for working closely with individuals in both protein engineering and immunology/oncology groups to innovate and develop the next generation of protein therapeutics for cancer treatment. The candidate will have access to state of the art protein and antibody engineering technologies, and will be expected to continue our tradition of developing world class methods and technologies that enhance our therapeutic discovery efforts. ROLE RESPONSIBILITIES The primary responsibilities include obtaining in-depth knowledge of the therapeutic targets of interest and using this information to formulate and design creative protein based therapeutics with high potential and new functionalities. This position requires the candidate to carry out hand-on lab work to apply protein engineering principles to generate novel protein therapeutics to target the immune system. The ideal candidate needs to have a strong understanding on how to purify and characterize protein therapeutics. This work will also include close collaborations with protein engineers and biologists to design and evaluate different protein therapeutics. The candidate needs to demonstrate strong desire and initiative to understand immunology and tumor biology, and help propose new ideas and techniques to discover next-generation therapeutics with unique functionalities. QUALIFICATIONS Ph.D. in Biological Science (biochemistry, biophysics, structural biology & molecular biology) or a related field (Chemical Engineering, Biomedical Engineering and Biological Engineering) At least 2 years of post-graduate experience in either an academic or industrial setting is preferred Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation. Track record of demonstrating analytical skills, creativity and unique problem solving skills Outstanding pro-active attitude, interpersonal, collaborative and oral communication skills Strong motivation, passion and commitment to science and engineering novel entities Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques Ability to analyze and interpret work published in the field and apply it appropriately Technical expertise should include strong protein biochemistry and molecular biology knowledge: cloning, expression and purification of proteins, biophysical characterizations, screening protein libraries, ELISA, and/or other biochemical and cell based assays Prior experience in working with immune system derived proteins like antibody, TCR, cytokine and antibody-like scaffold proteins is preferred Previous experience with protein engineering techniques such as phage display and yeast display is a plus Knowledge of translational work involving antibody and protein therapeutics in immunology and oncology would be of significant advantage EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. Additional Offer Details Grade: 8 Eligible for Relocation Package Eligible for Employee Referral Bonus Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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