Senior Scientist, Target Validation
September 22, 2016
  • Validates genes as potential drug targets by manipulating the expression of the target in vitro and in vivo
  • Contributes to the identification of new drug targets by bioinformatic analysis of gene expression data
  • Provides broad understanding of GI physiology to assess novel drug target mechanisms and pathways.
  • Delivers quantitative results with speed and accuracy to support departmental objectives

  • Plans, implements, and manages internal and external pre-clinical activities and interactions to deliver key experimental studies to support drug candidates in discovery research
  • Plans, oversees, and executes experiments characterizing target expression and cellular function in vitro and in vivo using a wide variety of cell and molecular biology techniques and disease models.
  • Responsible for target identification via analysis of complex expression datasets.
  • Manages projects as part of multidisciplinary teams both locally and globally.
  • Identifies and applies novel technology and expertise to enhance drug discovery research programs.
  • Manages relationships and projects with contract research organizations.
  • Interprets data clearly and concisely in documents and present results in an organized manner.
  • Communicates with project team and colleagues effectively and work well with others to meet experimental goals.
  • Contributes to the development of new disease models, explore disease mechanisms and mechanism of drug action in vitro and ex vivo and provide proof of concept for novel therapeutic targets
  • Delivers models and studies to facilitate selection of disease settings, discovery and validation of biomarkers.
  • Responds quickly to information learned from ongoing studies and provide input to target validation studies and drug discovery to guide program direction and prioritization.
  • Key responsibilities include target validation, compound differentiation, assay development and execution, pharmacodynamic and biomarker identification. He/She will closely collaborate/interact with other scientists from Leads Discovery Biology, Medicinal Chemistry, Structural Biology and Analytical Chemistry.
  • Exemplifies the highest scientific rigor and standards.
  •  Leads the area of novel target validation, providing clear data that guide decisions as to what projects are of highest scientific merit.
  • Proposes, designs, and executes in vivo and in vitro studies to support Takeda programs. 
  • Coordinates research and experiments both internally and in collaboration with external partners
  • Represents the Department at project team meetings and scientific meetings
  • Provides analysis and interpretation of data; write study reports and present data effectively in all settings and with participants of all levels of the organization.
  • Keeps up to date with appropriate literature and scientific developments and use knowledge to propose new programs or support current programs


  • Ph.D. in Molecular or Cell Biology or a related field with at least 4 years of relevant experience
  • MS/MA in Molecular or Cell Biology or a related field with at least 14 years relevant laboratory research experience OR,
  • BS/BA in Molecular or Cell Biology or a related field with at least 16 years relevant laboratory research experience
  • Demonstrated experience in preclinical GI drug discovery
  • Knowledge and expertise in gastrointestinal diseases
  • Technical expertise in methods assessing GI and enteric nervous system function, both in vitro and ex vivo
  • Experience with preclinical animal models of GI diseases
  • Ability to plan and execute experiments, critically evaluate and interpret data, and troubleshoot
  • Experience in target identification and validation for drug discovery
  • Experience with expression analysis techniques such as qPCR, immunofluorescence/immunhistochemistry
  • Knowledge and experience with tissue processing and imaging techniques such as confocal microscopy
  • Experience in analyzing gene expression data
  • Experience with animal handling, drug administration, knowledge of mouse anatomy and tissue dissection
  • Familiar with microarray and RNA sequencing technologies
  • Demonstrated ability to multi-task effectively
  • Willingness to work in a team-oriented, dynamic and changing environment
  • Skilled in statistical analysis and graphing programs
  • Ability to work and communicate effectively with colleagues of differing backgrounds and experience levels


  • Carrying, handling and reaching for objects up to 25 lbs
  • Able to work in a lab environment
  • Exposure to hazardous and toxic chemicals
  • Potential exposure to rodent allergens


  • Occasional travel, ~10%

we are driven to improve people's lives

Takeda is an EEO employer of minorities, women, disabled, protected veterans. For more information, visit

No Phone Calls or Recruiters Please.


A little about us:
Takeda fosters an inclusive environment where all employees are empowered, supported and inspired to use their unique talents toward our mission to serve patients.

Know someone who would be interested in this job? Share it with your network.