Senior Scientist, Target Validation
Location:
Posted:
September 22, 2016
Reference:
1602173
OBJECTIVES:
  • Validates genes as potential drug targets by manipulating the expression of the target in vitro and in vivo
  • Contributes to the identification of new drug targets by bioinformatic analysis of gene expression data
  • Provides broad understanding of GI physiology to assess novel drug target mechanisms and pathways.
  • Delivers quantitative results with speed and accuracy to support departmental objectives
ACCOUNTABILITIES:

  • Plans, implements, and manages internal and external pre-clinical activities and interactions to deliver key experimental studies to support drug candidates in discovery research
  • Plans, oversees, and executes experiments characterizing target expression and cellular function in vitro and in vivo using a wide variety of cell and molecular biology techniques and disease models.
  • Responsible for target identification via analysis of complex expression datasets.
  • Manages projects as part of multidisciplinary teams both locally and globally.
  • Identifies and applies novel technology and expertise to enhance drug discovery research programs.
  • Manages relationships and projects with contract research organizations.
  • Interprets data clearly and concisely in documents and present results in an organized manner.
  • Communicates with project team and colleagues effectively and work well with others to meet experimental goals.
  • Contributes to the development of new disease models, explore disease mechanisms and mechanism of drug action in vitro and ex vivo and provide proof of concept for novel therapeutic targets
  • Delivers models and studies to facilitate selection of disease settings, discovery and validation of biomarkers.
  • Responds quickly to information learned from ongoing studies and provide input to target validation studies and drug discovery to guide program direction and prioritization.
  • Key responsibilities include target validation, compound differentiation, assay development and execution, pharmacodynamic and biomarker identification. He/She will closely collaborate/interact with other scientists from Leads Discovery Biology, Medicinal Chemistry, Structural Biology and Analytical Chemistry.
  • Exemplifies the highest scientific rigor and standards.
  •  Leads the area of novel target validation, providing clear data that guide decisions as to what projects are of highest scientific merit.
  • Proposes, designs, and executes in vivo and in vitro studies to support Takeda programs. 
  • Coordinates research and experiments both internally and in collaboration with external partners
  • Represents the Department at project team meetings and scientific meetings
  • Provides analysis and interpretation of data; write study reports and present data effectively in all settings and with participants of all levels of the organization.
  • Keeps up to date with appropriate literature and scientific developments and use knowledge to propose new programs or support current programs

Qualifications EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • Ph.D. in Molecular or Cell Biology or a related field with at least 4 years of relevant experience
  • MS/MA in Molecular or Cell Biology or a related field with at least 14 years relevant laboratory research experience OR,
  • BS/BA in Molecular or Cell Biology or a related field with at least 16 years relevant laboratory research experience
  • Demonstrated experience in preclinical GI drug discovery
  • Knowledge and expertise in gastrointestinal diseases
  • Technical expertise in methods assessing GI and enteric nervous system function, both in vitro and ex vivo
  • Experience with preclinical animal models of GI diseases
  • Ability to plan and execute experiments, critically evaluate and interpret data, and troubleshoot
  • Experience in target identification and validation for drug discovery
  • Experience with expression analysis techniques such as qPCR, immunofluorescence/immunhistochemistry
  • Knowledge and experience with tissue processing and imaging techniques such as confocal microscopy
  • Experience in analyzing gene expression data
  • Experience with animal handling, drug administration, knowledge of mouse anatomy and tissue dissection
  • Familiar with microarray and RNA sequencing technologies
  • Demonstrated ability to multi-task effectively
  • Willingness to work in a team-oriented, dynamic and changing environment
  • Skilled in statistical analysis and graphing programs
  • Ability to work and communicate effectively with colleagues of differing backgrounds and experience levels

 PHYSICAL DEMANDS:

  • Carrying, handling and reaching for objects up to 25 lbs
  • Able to work in a lab environment
  • Exposure to hazardous and toxic chemicals
  • Potential exposure to rodent allergens


TRAVEL REQUIREMENTS:

  • Occasional travel, ~10%




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Schedule
Full-time
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