Sr Principal Scientist
Company: Bristol-Myers Squibb
Posted: January 26, 2017
Reference ID: 1700347
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. And driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
Bristol-Myers Squibb (BMS) Department of Metabolism and Pharmacokinetics seeks an experienced scientist and leader who is passionate about drug hunting in the areas of oncology biologics discovery (e.g., cancer immunotherapeutics, antibody drug conjugates, etc.). The selected individual is expected to serve as a local leader at our expanding site in Redwood City, CA, and represent the Department on drug discovery working groups and early clinical development teams to formulate program strategies and influence decision-making. The discovery program-related activities are generally centered on demonstrating proof-of-concept for novel targets, selecting/characterizing drug candidates, and projecting human starting and efficacious doses with the ultimate goal of improving drug candidate design, delineating differentiation strategies, and facilitating translational PK/PD efforts from discovery to development. At BMS, we take pride in applying model-based approaches for the quantitative integration of preclinical Pharmaceutics/PK/PD/efficacy/toxicity data in order to broadly impact on drug discovery and development processes. A clear understanding of PK/PD principles and their application to drug discovery is critical to this role. In addition, the person is expected to supervise junior scientists and provide scientifically sound guidance in hypothesis generation and problem solving. Furthermore, to effectively assess developability risk in the area of oncology, the selected candidate is expected to build a close and productive working relationship with biologists as well as scientists from other functional areas within the site and across geographic locations.
• A Ph.D. in pharmacokinetics or other related discipline, with ≥8-year industrial experience, is required.
• A sound understanding of PK and PD principles and demonstrated problem-solving skills are essential to this job.
• Hands-on modeling experience is a significant plus.
• In addition, strong communication skills and ability to influence and cooperate in a multi-discipline team setting are required for this function.