Sr. Principal Scientist, T-cell Biology and Characterization

  • Company: Pfizer
  • Location: South San Francisco, California
  • Posted: February 01, 2017
  • Reference ID: 1046438

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. Role Summary We are seeking a highly motivated, results-oriented, self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility, to join a new and dynamic team responsible for developing clinical manufacturing processes and characterization of allogeneic Chimeric Antigen Receptor T cell (CART) therapies. The successful candidate will lead efforts to develop heightened T-cell product understanding through application of molecular and T cell biology approaches to identify and measure attributes and/ or biomarkers critical for safety, functional activity and consistency of this novel engineered cell therapy modality, and work in close collaboration with key stakeholders, including the CART Research and Analytical R&;D groups. Responsibilities - Provide senior, strategic and technical, molecular immunology/ T cell biology leadership for cell and molecular characterization of allogeneic CART products, and starting donor PBMCs, to inform product understanding, process/ product relationships and batch-to-batch consistency - Lead/ contribute to the establishment of methods to characterize and understand the impact of cell engineering steps on the genome, biology and function of engineered T-cell products - particularly with regard to product safety (on-/ off-target effects and translocations) and efficacy - Lead/ contribute to the establishment of methods to characterize and understand the impact of donor-to-donor variability on engineered T-cell product genotype and phenotype with regard to safety (potential for alloreactivity/ GvHD) and efficacy - Lead/ contribute to the establishment of programs to identify relevant biomarkers for desired CART potency and safety characteristics and to demonstrate product consistency (donor-to-donor/ process changes) - Lead/ contribute to relevant and impactful innovation programs (internally and external collaborations) to enhance cell characterization technologies and work-processes, aligned with emerging business drivers and Regulatory expectations - Contribute to Project Technical Teams to ensure effective integration at all levels. Communicate and collaborate effectively to ensure seamless interfaces and interactions within the group and across all stakeholder groups - Demonstrate strong leadership, personal accountability and interpersonal skills, and capability for mentoring junior colleagues (direct reports and others), and establish safe, high-quality lab practices - Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports, and contribute to Regulatory Filings and responses to Regulatory questions as appropriate - Present data/ strategy to scientists and management in internal and external venues (technical meetings, Project Team meetings, conferences) and publish in peer-reviewed journals, as appropriate - Maintain familiarity with the relevant current literature and its application to T-cell characterization and understanding Education and Experience PhD degree in Immunology/ Molecular Biology with 10+ years of post-graduate experience in relevant roles in academia (industry a plus), in the development of methods/ tools for investigation and characterization of T cell genotype, phenotype and function - preferably for cell-based therapies. Technical Skills Requirements: - T cell biology, molecular immunology, 'omics analysis, NGS (bioinformatics a plus) - Leading and managing a team - Ability to design and deliver novel solutions to challenging problems - a track record of innovation and publication PHYSICAL/MENTAL REQUIREMENTS: Ability to perform complex data analysis Ability to analyze and interpret work published in the field and use it to place own work in context NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS: Some travel to other Pfizer sites and national/ international collaborators may be required Other Job Details: Eligible for Relocation Package Eligible for Employee Referral Bonus EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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