Sr. Principal Scientist, PharmSci Team Leader
Location:
Posted:
August 31, 2016
Reference:
1037760


About the company
A career at the company offers opportunity, ownership and impact.

All over the world, the company colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. the company, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description
A Biotherapeutics Pharm Sci Team Leader (PSTL) leads multiple interdisciplinary Pharmaceutical Sciences Project Teams (PSPTs). The PSTL also acts as the single point of accountability for Biotherapeutics Pharmaceutical Sciences (BTx PS) on the Asset or Program teams for the assigned projects. The Biotherapeutics PSTL may be assigned to lead projects at any development stage from discovery stage to Proof of Concept (PoC), depending on the needs of the portfolio.

The position offers the unique opportunity to apply scientific expertise to help guide BTxPS strategies regarding novel approaches in immune-oncology, Chimeric antigen receptor T-cell therapy, oncolytic viruses, and gene therapy space. The individual will be responsible to engage other subject matter experts and key members of the company leadership, as needed.

Responsibilities
1) Leading BTx PS Project Teams, which are comprised of scientists from the key disciplines in BTx PS and are responsible for Pharmaceutical Sciences (PS) strategy development and planning execution for the assigned projects
2) Represents BTx PS as a member of the Asset/Project Team; responsible to drive overall strategy for the projects, which include both internal and in-licensed projects; key liaison between Pharm Sci leadership (and Science and Technology lines) and the RU/BU in which the project is being developed
3) Working with key stakeholders across commercial, clinical and the company Global Supplies (PGS) to define the product concept and lead the operational planning for assigned projects
4) Interfacing with Drug Safety, Dev Ops, Global Clinical Supplies, and Clinical teams to develop a clinical supply and administration strategy
5) Acting as an ambassador for BTx PS to project team leaders, governance bodies and other key stakeholders; representing the BTx PS viewpoint to greater the company and actively educating stakeholders on BTx PS core expertise(s), opportunities, risks, and work processes
6) Contributing effectively to the BTx Project Team, ensuring productive two-way communication and alignment of plans between PharmSci and other Lines or Therapeutic Area Strategies
7) Facilitating communication within BTx PS and ensuring alignment between internal Pharm Sci lines and external partner/enabling lines.
8) Good scientific understanding of novel approaches in immune-oncology, Chimeric antigen receptor T-cell therapy, oncolytic viruses, and gene therapy to effectively communicate scientific progress and challenges
9) Ensuring effective leadership of BTx projects through appropriate governance structures (e.g., PrePOC Management Team (PPMT)),
10) Working with Procurement and BTx PS Outsourcing Specialists to manage interactions with third party manufacturers and other vendors necessary for the projects
11) Ensuring that the PSPT maintains accurate and timely PS project plans, resource forecasts, annual budgets, and related deliverables for the assigned projects
12) Contributing to continuous improvement efforts within BTx PS and across greater the company through such activities as Limited Duration Teams, "Lessons Learned" exercises, and mentoring other PSTLs and team members
13) Lead out-licensing of projects or working with an external partner for in-licensing a candidate. This will require close interaction with business development, licensing management team and other functions.

Qualifications
Minimum Requirements: Master level education in biology, biochemistry, biomedical engineering or an analytical chemistry-based discipline plus 10 years of experience in drug development; demonstrated success in leading scientific teams; excellent oral and written communication skills.

Desirable: Doctorate level education plus 7 or more years in drug development. Scientific expertise in any of the following areas: virology, immunology, viral vector design and manufacturing, gene editing.

• Working experience in pharmaceutical sciences and process development is highly desirable.
• Specific experience in developing manufacturing/analytical/pharmaceutical processes to support clinical trials and commercial scale-up of biotherapeutics (e.g., CAR-T, gene therapy vectors, antibodies etc) is also desirable.
• Strong record applying innovative and complex pharmaceutical sciences approaches to drug development in a fast-paced, matrixed project team environment; understanding of requirements for commercialization.
• The successful candidate will be capable of independent problem solving and working with minimal direction under most circumstances.
• Applicants should demonstrate strongly collaborative behaviors and teamwork and demonstrate expertise in most or all of the following: team dynamics, coaching, negotiation, motivating and other soft skills necessary to foster team effectiveness in a matrixed environment.
• The successful candidate will also possess strong oral and written communication skills.
• The successful candidate also needs strong situational awareness, as he/she will often be asked to communicate complex scientific information across a broad spectrum of stakeholders (e.g., lab scientists to executive leadership).
• Strong analytical and computer skills are required.

PHYSICAL/MENTAL REQUIREMENTS
Strong analytical and computer skills are required. Sitting, walking, standing as required in an office environment.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Requires ~15-25% to attend meetings, conferences, etc.

Other Information - Internal
Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

EEO & Employment Eligibility
the company is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. the company also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. the company is an E-Verify employer.
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