The Senior Research Associate II (SRA II), Discovery Biology will work within the Target Validation team and provide support in GI research. The SRA II will support pharmacological and target validation experiments in animal models of GI disorders with an emphasis on functional ex vivo studies. This position will work independently to develop new protocols and interact closely with our team of scientists to validate new targets for GI indications. The position represents an excellent opportunity to further basic laboratory and research skills in a highly dynamic group. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in novel research.
• Works independently to conduct ex vivo tissue experiments for functional validation of newly identified drug targets
• Conducts cell and molecular biology to validate expression of newly identified drug targets
• Delivers quantitative results with speed and accuracy to support departmental objectives
• Exemplifies the highest scientific rigor and standards.
• Works and communicates effectively with colleagues of differing backgrounds and experience levels
• Develops and establishes new techniques and protocols
• Provides analysis and interpretation of data; writes study reports and presents data effectively in all settings and with participants of all levels of the organization.
• Provides guidance and mentorship and may oversee junior staff
Qualifications EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
• BS/BA in a relevant field of biology or equivalent field and at least 8 years of experience in drug discovery, particularly pharmacodynamic studies in animal models of disease or MS/MA in a relevant field of biology with 6 or more years of relevant experience
• Experience with ex vivo (GI or other) physiology techniques (Ussing chamber, organ bath, whole mount sectioning)
• Experience in a wide range of cell and molecular biology techniques including mammalian cell culture, cell-based functional assays, confocal immunofluorescence and immunohistochemistry
• Familiarity with GI anatomy, physiology and biology
• In vivo experience working with rodent and human tissue
• Skilled in statistical analysis, graphing programs, PowerPoint presentations and Excel
• Excellent written and verbal communication skills and possess the ability to work independently as well as part of a team
• Ability to design and interpret experiments collaboratively and independently
• Ability to manage multiple tasks and priorities to achieve desired goals
• Excellent attention to detail
• Self-directed researcher with an enthusiasm for learning and implanting new techniques and technologies
• Willingness to travel to various meetings, including overnight trips. Some international travel may be required.
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