ROLE SUMMARY • Oversee execution of comprehensive early clinical development strategies for Pfizer -oncology discovery assets. Development spans pre-IND, First in patient through Proof of Concept. • Work collaboratively across multiple research units to develop integrated clinical portfolio strategies. • Collaborate with key late phase development partners in Pfizer Oncology to align target populations and aggressive Proof of Concept plans, allowing for seamless late phase development. • Lead early FIP approaches that allow for rapid dose and combination execution. • Work collaboratively with multiple research units across Pfizer to drive early Candidate Selection of oncology early pipeline. ROLE RESPONSIBILITIES Develop innovative early clinical development plans that drive early decision making based upon objective clinical safety and efficacy response measures. Introduce early plans of development in combination with adjunctive immune-oncology assets. Advise on development concepts in vaccine-based oncology programs. Work collaboratively with Pfizer Oncology to develop expedited Proof of Concept programs that lead to seamless late stage development. Collaborate with external experts to drive innovation in early clinical development plans and translational/precision medicine. Represent Pfizer at critical regulatory interactions. Membership in Technical Review Committee (TRC) to ensure highest level of rigor and scientific integrity of clinical programs and protocols. Work in partnership with Team Leader(s) to ensure delivery of high-quality, cost-effective programs that are delivered on time and within budget, while maintaining the necessary resources needed to deliver the program. Meet regularly with senior leaders, including CSOs on Oncology early development Collaboration with Pfizer External Research, Development, and Innovation (ERDI), WRD and ORD leadership to identify new preclinical or pre-PoC candidates and conduct due diligence as part of integrated assessments. Identify and escalate issues in a timely manner as appropriate. Meet with other Pfizer Oncology and Pfizer senior leaders as requested to keep them fully informed of issues of high priority related to Oncology. QUALIFICATIONS MD, MD/PhD or equivalent with extensive clinical experience. At least 10 years of oncology development experience within the Biotech or Pharmaceuticals industry, with focus in early development in Oncology. Ability to collaborate across multiple organizations in the pre-PoC discovery environment. Ability to lead in a matrixed team environment. Understanding of the drug development continuum from pre-POC to post-POC and commercialization. Understanding of related disciplines (e.g. biostatistics, regulatory, pre-clinical pharmacology, pharmaceutical sciences). Demonstrated scientific productivity (publications, abstracts, etc.). A thorough understanding of Oncology and cancer biology and its relationship to drug development. Experience in functioning effectively as a member of a matrixed/multidisciplinary team. Insight into and understanding of principles related to evaluating business deal structures including commercial collaborations, acquisitions, and divestitures. Experience in budgetary management and decision making. Demonstrated effectiveness in people management, communication and colleague development. Demonstrated effective negotiating, influencing, interpersonal and leadership skills. Exceptional verbal and written communication and presentation skills. Ability to collaborate effectively both inside and outside the organization. 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